The renamed Tennessee Titans opened Adelphia Coliseum on September 12, 1999, against the Cincinnati Bengals. After the Tennessee Oilers had two temporary homes — the Liberty Bowl in Memphis and Vanderbilt Stadium in Nashville — the previous two seasons, the franchise finally had its permanent home along the banks of the Cumberland River.

The Titans nearly blew a 26-7 lead but hung on the defeat the Bengals 36-35. Few fans figured as they filed out of the new stadium that the narrow win would kickstart the greatest season in franchise history. Under head coach Jeff Fisher, the Titans went 13-3, earned a wild card berth and then won three playoff games en route to their first Super Bowl appearance. Tennessee eventually lost to the St. Louis Rams in one of the greatest Super Bowl finishes ever but the 1999 Titans set the stage for pro football in Music City.